Table 4.

Brain regions with significant increases in FC relative to baseline and change in placebo (Methylene Blue > Placebo and Post Intervention > Pre Intervention)

Source Seed (location)	Target	pFDR	k	z’	t
Left ventral intraparietal sulcus	Right intracalcarine cortex, right lingual gyrus	0.0003	388	0.26	5.11
Posterior cingulate, precuneus	Right insular cortex	0.003	265	0.22	7.72
Left frontal eyefield	Left precentral gyrus, left middle frontal gyrus	0.006	254	0.25	4.92
Left temporal pole	Left superior frontal gyrus, left paracingulate gyrus	0.008	258	0.25	5.7
Left intracalcarine cortex	Lateral occipital cortex superior division	0.022	189	0.29	4.85
Left hippocampus	Cerebellum 9 right	0.025	187	0.2	7.04
Right middle frontal gyrus	Right inferior temporal gyrus (temporooccipital), temporal occipital fusiform cortex, right middle temporal gyrus (temporooccipital part), cerebellum crus1	0.031	209	0.24	5.47
Right temporal pole	Left superior frontal gyrus, left paracingulate gyrus	0.037	187	0.26	4.72

Cluster corrected pFDR <0.05, k = no. of voxels (1.719 × 1.719 × 4 mm³ per voxel), z’ = Fisher corrected correlation, 26 degrees of freedom, N = 15 MB and N = 13 Placebo, detailed results in Table S1