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. 2016 Sep 8;166(6):1459–1470.e11. doi: 10.1016/j.cell.2016.08.005

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S3 — Characterization and Structural Analysis of BG505 GT3.1 SOSIP and ABC SOSIP Trimers, Related to Figure 1

(A) Negative-stain 2D class average images of the GT3.1 SOSIP, CD4bs-B SOSIP and CD4bs-C SOSIP are shown. 37% of GT3.1 SOSIP trimers were classified as closed native-like trimers, 63% as open native-like trimers and 0% as non-native-like trimers.

(B) DSC thermogram of GT3.1 SOSIP.

(C) ELISA analysis of mature and GLRev VRC01-class Ab binding to BG505 SOSIP and BG505 GT3.1 SOSIP.

(D) SPR sensograms of BG505 SOSIP and BG505 GT3.1 SOSIP as analytes and non-nAbs IgGs as ligands. Maximum analyte concentrations were 990 nM and 1.3 uM for BG505 SOSIP and BG505 GT3 SOSIP, respectively, and lower concentrations teseted were 4-fold dilutions.