Fig. 3.

Production and release of immunoglobulins from CSR-deficient patients and CSR-like CVID patients upon B cell activation. IgM and IgG levels were measured in the supernatants by ELISA after 6 days of culture. Plotting multiple experiments per patient group (N = 2–5). Immunoglobulin production shown is normalized to that of the healthy control samples used in each separate experiment, production of Ig’s after stimulated with CpG/IL-2 is set at 100 %. Controls range from 2700 to 5000 pg/ml for IgG and 4000–9000 pg/ml for IgM. ND not done