Fig. 2.

Efficacy during the open-label extension (OC, full analysis set). a Least squares mean change from acute phase baseline in YMRS total score to end of treatment by visit; b Mean (SD) change in CGI-BP overall score from acute phase baseline to end of treatment by visit. The CGI-BP overall score ranged from 1 (normal, not at all ill) to 7 (among the most extremely ill patients). Decreases from baseline within a treatment group were indicative of an improvement. The YMRS total score could range from 0 (all symptoms absent) to 60 (all symptoms extreme). Decreases from baseline within a treatment group are indicative of an improvement in symptoms. Full analysis set is all patients ≤17 years of age who received ≥1 dose of trial medication and had both baseline and ≥1 post-baseline in-treatment YMRS total scores in the acute and extension trial. CGI-BP Clinical Global Impression scale for use in bipolar illness, OC observed case, SD standard deviation, YMRS Young Mania Rating Scale