Table 4. Comparison of Adiponectin rs266729 and rs2241766 Genotypes With Clinicopathological Parametersa.
| Parameters | rs266729 | rs2241766 | ||
|---|---|---|---|---|
| GC+GG | CC | GG+GT | TT | |
| CAD+NAFLD | N = 119 | N = 127 | N = 120 | N = 126 |
| Age, y | 46.54 ± 11.04 | 46.39 ± 12.08 | 46.39 ± 11.21 | 45.94 ± 11.09 |
| Gender, Female/Male | 57/62 | 62/65 | 59/61 | 60/66 |
| Height, m | 1.67 ± 0.06 | 1.67 ± 0.08 | 1.67 ± 0.07 | 1.68 ± 0.02 |
| Weight, kg | 67.53 ± 6.31 | 65.98 ± 7.02 | 68.21 ± 5.98 | 67.34 ± 6.56 |
| Smoker, No. (%) | 67 (56.30) | 61 (48.03) | 58 (48.3) | 63 (50.0) |
| BMI, kg/m2 | 24.29 ± 3.76 | 25.31 ± 3.32 | 23.67 ± 4.62 | 24.54 ± 3.21 |
| Hypertension, No. (%) | 60 (50.4) | 61 (48.0) | 58 (48.3) | 60 (47.6) |
| ALT, U/L | 44.52 ± 21.43 | 43.62 ± 22.36 | 44.31 ± 21.54 | 43.96 ± 21.09 |
| AST, U/L | 41.34 ± 20.31 | 40.56 ± 21.09 | 40.99 ± 21.23 | 39.62 ± 20.97 |
| TG, mmol/L | 2.85 ± 1.08 | 2.21 ± 0.96b | 2.83 ± 1.00 | 2.68 ± 0.96c |
| TC, mmol/L | 5.62 ± 1.34 | 5.21 ± 0.99d | 5.67 ± 1.02 | 5.36 ± 1.01 |
| FPG, mmol/L | 5.33 ± 0.73 | 5.01 ± 0.61e | 5.27 ± 0.63 | 5.17 ± 0.59 |
| HDL, mmol/L | 1.37 ± 0.41 | 1.34 ± 0.42 | 1.43 ± 0.39 | 1.41 ± 0.41 |
| LDL, mmol/L | 3.43 ± 0.94 | 2.96 ± 0.89f | 3.29 ± 0.97 | 3.21 ± 0.71 |
| Adiponectin, ug/mL | 13.62 ± 4.32 | 16.82 ± 4.47g | 13.38 ± 3.21 | 14.98 ± 3.92 |
| CAD-NAFLD | N = 96 | N = 151 | N = 120 | N = 127 |
| Age, y | 62.87 ± 9.65 | 62.09 ± 9.87 | 62.41 ± 9.51 | 62.08 ± 9.61 |
| Gender, Female/Male | 49/47 | 73/78 | 58/62 | 63/64 |
| Height, m | 1.67 ± 0.06 | 1.67 ± 0.05 | 1.66 ± 0.08 | 1.67 ± 0.06 |
| Weight, kg | 66.58 ± 6.71 | 67.32 ± 7.01 | 66.42 ± 6.52 | 66.67 ± 6.81 |
| Smoker, No. (%) | 39 (40.6) | 65 (43.0) | 41 (34.2) | 46 (36.2) |
| BMI, kg/m2 | 24.89 ± 3.62 | 25.01 ± 3.01 | 24.42 ± 3.31 | 24.65 ± 3.45 |
| Hypertension, No (%) | 38 (39.6) | 60 (39.7) | 43 (35.8) | 47 (37.0) |
| ALT, U/L | 41.02 ± 21.32 | 40.61 ± 20.56 | 41.45 ± 20.67 | 41.21 ± 20.11 |
| AST, U/L | 41.34 ± 22.09 | 40.21 ± 21.89 | 41.01 ± 21.09 | 40.56 ± 21.11 |
| TG, mmol/L | 2.23 ± 0.81 | 2.01 ± 0.75h | 2.21 ± 0.76 | 2.17 ± 0.69i |
| TC, mmol/L | 5.04 ± 0.91 | 5.05 ± 0.89 | 5.04 ± 0.84 | 5.04 ± 0.69 |
| FPG, mmol/L | 5.21 ± 0.61 | 4.94 ± 0.57j | 5.19 ± 0.21 | 5.16 ± 0.22 |
| HDL, mmol/L | 1.34 ± 0.32 | 1.36 ± 0.41 | 1.32 ± 0.25 | 1.35 ± 0.32 |
| LDL, mmol/L | 2.63 ± 0.67 | 2.61 ± 0.68 | 2.59 ± 0.65 | 2.61 ± 0.67 |
| Adiponectin, ug/mL | 13.26 ± 4.21 | 15.56 ± 4.31k | 14.26 ± 3.89 | 15.63 ± 4.01 |
| Controls | N = 85 | N = 219 | N = 119 | N = 185 |
| Age, y | 61.09 ± 9.21 | 61.23 ± 9.31 | 62.21 ± 9.02 | 61.59 ± 9.11 |
| Gender, Female/Male | 41/44 | 111/108 | 57/62 | 95/90 |
| Height, m | 1.68 ± 0.07 | 1.67 ± 0.09 | 1.68 ± 0.07 | 1.68 ± 0.08 |
| Weight, kg | 66.65 ± 6.32 | 67.32 ± 5.94 | 67.01 ± 6.01 | 67.21 ± 5.45 |
| Smoker, No. (%) | 29 (34.1) | 79 (36.1) | 45 (37.8) | 64 (34.6) |
| BMI, kg/m2 | 23.11 ± 3.21 | 22.97 ± 3.01 | 24.01 ± 3.41 | 23.07 ± 3.01 |
| Hypertension, No. (%) | 31 (36.5) | 80 (36.5) | 37 (31.1) | 62 (33.5) |
| ALT, U/L | 20.31 ± 7.21 | 20.56 ± 6.91 | 21.21 ± 7.09 | 20.56 ± 6.18 |
| AST, U/L | 19.71 ± 7.13 | 20.81 ± 8.07 | 19.76 ± 7.85 | 19.81 ± 8.02 |
| TG, mmol/L | 1.21 ± 0.41 | 1.41 ± 0.52 | 1.29 ± 0.33 | 1.36 ± 0.41 |
| TC, mmol/L | 4.32 ± 0.81 | 4.02 ± 0.71 | 4.01 ± 0.36 | 4.28 ± 0.52 |
| FPG, mmol/L | 4.86 ± 0.42 | 4.93 ± 0.31 | 4.92 ± 0.41 | 4.94 ± 0.44 |
| HDL, mmol/L | 1.54 ± 0.46 | 1.55 ± 0.41 | 1.54 ± 0.42 | 1.54 ± 0.42 |
| LDL, mmol/L | 2.59 ± 0.76 | 2.61 ± 0.71 | 2.61 ± 0.76 | 2.60 ± 0.68 |
| Adiponectin, ug/mL | 18.78 ± 3.21 | 19.02 ± 3.11 | 19.01 ± 2.97 | 19.36 ± 3.02 |
aValues are expressed as mean ± SD unless otherwise indicated.
bP = 0.031.
cP = 0.039.
dP = 0.034.
eP = 0.007.
fP < 0.001.
gP < 0.001.
hP = 0.014.
iP = 0.042.
jP = 0.038.
kP < 0.001.