Table 1.
Features of available software for drugs combinations analyses. L: Loewe, B: Bliss, H: HSA, DR: Dose–response curve, M: Matrix view, C: contours, S: surfaces, I: Isobolograms, SM: synergy mapped to dose–response surfaces, F: Fa related curves, see (Chou, 2010). Note: we have not included CombiTool (Dressler et al., 1999) because it does not appear to be available anymore
| Combenefit | ChaliceTM | Genendata Screener® | CompuSyn | MacSynergy™ II | |
|---|---|---|---|---|---|
| Available | Free | Commercial | Commercial | Free | Free |
| Source code | Yes | No | No | No | Spreadsheet |
| Replicates | Yes | Yes | Yes | No | Yes |
| Fitting (Hill model) | 3 params | 3 params | 3 params + baseline | 2 params (no max) | No |
| Synergy models | L,B,H (+planned) | L,B,H and 2 others | L,B,H | L based | B |
| Scores/metrics | Several | Several | Several | No | No |
| Graphics | DR,M,C,S,SM | DR,M,C,I | DR,M,C,I | DR,I,F | C,S |
| Data input | File | File | File | Manual | Manual |
| HTS suitable | Yes | Yes | Yes | No | No |