Table 4.
Predicted top 10 new genes for PD by Know-GENE
| Gene | Score | Evidence of support or disapprove |
|---|---|---|
| NUP62_HUMAN | 0.971 | Supported by ref. (Zatloukal et al., 2002) |
| HD_HUMAN | 0.953 | Causes Huntington’s disease that shares the same malfunctions within the motor sector of the nervous system as PD (Delcomyn, 1998); http://serendip.brynmawr.edu/bb/neuro/neuro98/202s98-paper3/Sangaramoothy3.html |
| PANK2_HUMAN | 0.953 | Disapproved by ref. (Klopstock et al., 2005) |
| TOR1A_HUMAN | 0.952 | Supported by ref. (Leung et al., 2001) |
| TOM40_HUMAN | 0.935 | Supported by ref. (Bender et al., 2013) |
| STX6_HUMAN | 0.922 | Disapprove by ref. (Trinh et al., 2013) |
| THAP1_HUMAN | 0.890 | Support: THAP1 gene is part of a family of THAP proteins that bind specific DNA sequences and regulate cell proliferation through the pRB/E2F cell cycle target genes, a pathway recently proposed to be involved in cell death in PD (Höglinger et al., 2007; Houlden et al., 2010) |
| IRF4_HUMAN | 0.875 | Supported by ref. (Soreq et al., 2008) |
| E2AK3_HUMAN | 0.875 | Supported by ref. (Dzamko et al., 2014) |
| A4_HUMAN | 0.862 | Supported by ref. (Schulte et al., 2015) |