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. Author manuscript; available in PMC: 2016 Sep 11.
Published in final edited form as: Sci Transl Med. 2015 May 13;7(287):287ra72. doi: 10.1126/scitranslmed.3009986

Fig. 1. Correlation of DRG expression of Chrna6 and mechanical allodynia after SNI in inbred mice.

Fig. 1

SNI surgery was performed on 25 inbred mouse strains, and withdrawal thresholds of the ipsilateral hind paw to von Frey fiber stimulation were measured. Symbols in A (n=139) represent mean ± SEM paw withdrawal threshold on each testing day; bars in B (n=4–6 mice/strain) represent mean ± SEM percentage of maximum possible allodynia (see Materials and Methods online). (C) The top 7 correlations (Pearson’s r; all P<0.005) between the strain means shown in B and basal DRG expression levels of ≈45,000 probesets in these same strains. (D) The correlation between allodynia and basal DRG expression (in arbitrary units) of probeset 1450426_at (Chrna6); symbols represent individual strain values. Symbol abbreviations are self-explanatory except for: Bc, BALB/cBy; B6, C57BL/6; BR, C57BR/cd; D2, DBA/2. (E) Average expression across all strains of all Chrn* genes. Bars represent basal DRG expression (in arbitrary units) ± SD.