A 38-year-old male patient with a high-grade glioma (glioblastoma multiforme, WHO grade IV). T2-weighted EPI at b=0 with the tumor ROI encircled in green (A) and FROC parameter maps of D (B), β (C), and μ (D) with the tumor ROIs indicated by the black contours (see On-line Fig 2 for a complete set of images including axial precontrast T1-weighted FLAIR, postcontrast T1-weighted FLAIR, T2-weighted FLAIR, and T2-weighted PROPELLER images). Compared with the patient with an oligodendroglioma in Fig 1, all 3 FROC parameters exhibited lower values. a.u. indicates arbitrary units. The color scale in (B) is expressed in square micrometers/millisecond.