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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Curr Opin Chem Biol. 2016 Jun 17;33:88–94. doi: 10.1016/j.cbpa.2016.06.005

Figure 2. OGT and O-GlcNAcylation are key regulators of transcription activation.

Figure 2

OGT is targeted to chromatin by Tet proteins, where OGT and O-GlcNAcylation regulates the conversion of 5mC to 5hmC. At promoters, OGT is a scaffold at the center of epigenetic regulators and O-GlcNAcylation of some of these proteins regulates their activity leading to gene activation. At gene specific promoters, OGA is recruited to the chromatin, where it forms a complex with the histone methyltransferases: p300 and CBP. Acetylation of H3 and H4 are mainly associated with gene activation. O-GlcNAcylation: G; methylation: me; ubiquitination: Ub; and acetylation: Ac.