Table 2.

Perturbations on neurotransmitters and their effects on balance of mobiles

Perturbation	Mobile for GABAergic neurons#	Mobile for Glutamatergic neurons$	Overall Mobile%
ACh antagonist on Glu neurons in PFC	⟺	DA/NE down GABA down	5-HT/DA/NE down 5-HT down GABA down
DA D2 antagonist on GABAergic neurons in striatum	⟺	⟺	ACh/Glu/GABA down
Activation of DA D1 on GABAergic neurons in striatum	⟺	⟺	GABA down ACh/Glu/GABA down
NMDA receptor agonist on GABAergic neurons in GPi	⟺	⟺	GABA down ACh/Glu/GABA down
NMDA receptor antagonist on GABAergic neurons in GPe	⟺	⟺	Glu down
Reuptake inhibitor of GABA release to Glu neurons in STN	⟺	⟺	ACh/Glu/GABA down GABA down
5-HT2 agonist on Glu neurons in Thalamus	⟺	ACh/Glu/GABA down Glu down	ACh/Glu/GABA down Glu down
NE α1 antagonist on DA neurons in VTA	NE down 5-HT down	ACh/Glu/GABA down NE down	ACh/Glu/GABA down 5-HT down
5-HT2 antagonist on GABA neurons in VTA	⟺	⟺	5-HT/DA/NE down DA down Glu down
Reuptake inhibitor of ACh release to DA in SNpc	⟺	DA/NE down GABA down	5-HT/DA/NE down 5-HT down GABA down
NE α1 antagonist on ACh neurons in LDT	⟺	ACh/Glu/GABA down	ACh/Glu/GABA down 5-HT down Glu down
Reuptake inhibitor of GABA release to 5-HT neurons in DRN	DA down	DA/NE down Glu down	ACh/Glu/GABA down DA down GABA down
Reuptake activation of GABA release to NE neurons in LC	⟺	⟺	5-HT/DA/NE down Glu down
NMDA receptor antagonist on GABAergic neurons in DRN	⟺	⟺	5-HT/DA/NE down 5-HT down Glu down
5-HT2 agonist on GABA neurons in LC	⟺	⟺	ACh/Glu/GABA down GABA down

^#: the symbol “⟺“ indicates balance of a mobile.

^$: Text descriptions, such as DA/NE down, indicate an imbalanced state of a mobile; specifically, DA/NE down means the scale with DA and NE tilts down on the side of these neurotransmitters.

^%: For abbreviations, please refer to the legend of Figure 1.