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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Neurobiol Aging. 2016 Jun 17;46:58–67. doi: 10.1016/j.neurobiolaging.2016.06.008

Figure 1.

Figure 1

Identification of Hp1bp3 as top candidate modulator of cognitive aging (a) The BXD panel was derived by inbreeding the F2 progeny of a C57BL/6J (B6) and DBA/2J (D2) intercross. (b) Contextual fear memory (CFM) varies widely across 21 BXD strains (n = 2–8/strain, mean age = 15 ± 0.3 mo). Memory index was quantified by percent time spent freezing during 10 min test. (c) Genetic interval mapping revealed a significant CFM QTL on mouse chromosome 4 (Chr4: 137.5–140.5 Mb). Pink horizontal line: Genome-wide statistical significance (p = 0.05), Green additive effect line: D parental allele increases trait values, red: B allele increases trait values. Yellow tick marks: presence of genome sequence variant. (d) Hp1bp3 expression is highly correlated with CFM across BXD strains (Pearson r = 0.6, p < 0.05), with strains inheriting the D allele having lower levels of hippocampal Hp1bp3 and poorer CFM.