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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Neurobiol Aging. 2016 Jun 17;46:58–67. doi: 10.1016/j.neurobiolaging.2016.06.008

Figure 4.

Figure 4

Hp1bp3 knockout (KO) mice exhibit impairment on hippocampus-dependent long-term and working memory tasks. (a) Comparable baseline (BL) freezing and acquisition of conditioned fear (Acq. fear) by the final trial in wild-type (WT) and Hp1bp3 knock-out (KO) mice (n = 6/group) during contextual fear conditioning. (b) There were no differences in post-shock reactivity during fear conditioning training between WT and Hp1bp3 KO mice, indicating no differences in pain sensitivity. Videos were manually analyzed to determine the average length of activity burst for each mouse. WT = 2.6 ± 0.2 s, KO = 2.6 ± 0.2 s; t(1,10)= −0.11, p = 0.91. (c) KO mice were significantly impaired on CFM [t(10) = 3.10, p < 0.001)]. (d) KO mice also exhibited spatial working memory deficits [t(12) = 5.095, p < 0.001].