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The nine AD signature regions were hand-traced in FreeSurfer and included a) anterior medial temporal lobe, b) inferior temporal gyrus, c) temporal pole, d) angular gyrus, e) superior frontal gyrus, f) superior parietal lobule, g) supramarginal gyrus, h) precuneus, and i) inferior frontal sulcus. The occipital cortex (j) was used as a control region.
