4.

Cutoff points of DNA-ICM based on different pathologic types

Pathologic types	AUC	95% CI of AUC	P	Cutoff point	SE (%)	SP (%)	Youden's index
LGIN, low grade intraepithelial neoplasia; HGIN, high grade intraepithelial neoplasia; ESCC, esophageal squamous cell cancer; AUC, area under the curve; SE, sensitivity; SP, specificity.
LGIN	0.584	0.555-0.613	P<0.001	5, 802	67.0	46.7	0.137
HGIN	0.703	0.643-0.762	P<0.001	5, 803	83.1	45.3	0.284
ESCC	0.811	0.728-0.895	P<0.001	8, 002	68.0	76.9	0.449