5.
Screening ability of liquid-based cytology, DNA-ICM test and the combination (%)
| Methods | ≥LGIN | ≥HGIN | ESCC | ||||||||||||
| SE (95% CI) | SP (95% CI) | NPV (95% CI) | PPV (95% CI) | SE (95% CI) | SP (95% CI) | NPV (95% CI) | PPV (95% CI) | SE (95% CI) | SP (95% CI) | NPV (95% CI) | PPV (95% CI) | ||||
| DNA-ICM, DNA image cytometry; LGIN, low grade intraepithelial neoplasia; HGIN, high grade intraepithelial neoplasia; ESCC, esophageal squamous cell cancer; ASCUS, atypical squamous cells of undetermined significance; LISL, low grade squamous intraepithelial lesion; HISL, high grade squamous intraepithelial lesion; SE, sensitivity; SP, specificity; NPV, negative predictive value; PPV, positive predictive value. | |||||||||||||||
| Liquid-based cytology | ≥ASCUS | 32.0 (30.3-33.7) | 85.0 (83.7-86.3) | 83.9 (82.6-85.2) | 33.8 (32.1-35.5) | 59.0 (57.2-60.8) | 83.2 (81.8-84.6) | 98.2 (97.7-98.7) | 11.3 (10.1-12.5) | 70.3 (68.6-72.0) | 82.4 (81.0-83.8) | 99.5 (99.2-99.8) | 5.0 (4.0-5.8) | ||
| ≥LSIL | 12.8 (11.6-14.0) | 97.7 (97.2-98.2) | 82.4 (81.0-83.8) | 57.7 (55.9-59.5) | 38.0 (36.2-39.8) | 96.9 (96.3-97.5) | 97.7 (97.2-98.2) | 30.9 (29.2-32.6) | 56.8 (55.0-58.6) | 96.4 (95.7-97.1) | 99.4 (99.1-99.7) | 17.1 (15.7-18.5) | |||
| ≥HSIL | 4.7 (3.9-5.5) | 99.7 (99.5-99.9) | 81.3 (79.9-82.7) | 76.5 (79.9-78.1) | 26.0 (24.4-27.6) | 99.7 (99.5-99.9) | 97.4 (96.8-98.0) | 76.5 (74.9-78.1) | 51.4 (49.6-53.2) | 99.5 (99.2-99.8) | 99.4 (99.1-99.7) | 55.9 (54.1-57.7) | |||
| ESCC | 2.7 (2.1-3.3) | 99.9 (99.8-100) | 81.0 (79.6-82.4) | 83.3 (81.9-84.7) | 15.0 (13.7-16.3) | 99.9 (99.8-100) | 97.0 (96.4-97.6) | 83.3 (81.9-84.7) | 35.1 (33.3-36.9) | 99.8 (99.6-100) | 99.2 (98.9-99.5) | 72.2 (70.6-73.8) | |||
| DNA-ICM | ≥5, 802 | 67.0 (65.1-68.9) | 46.7 (44.7-48.7) | 85.9 (84.5-87.3) | 67.0 (65.1-68.9) | 83.1 (81.6-84.6) | 45.0 (43.0-47.0) | 98.8 (98.4-99.2) | 4.7 (3.9-5.5) | 96.0 (95.2-96.8) | 44.5 (42.5-46.5) | 99.9 (99.8-100) | 1.8 (1.3-2.3) | ||
| ≥5, 803 | 66.4 (64.5-68.3) | 46.9 (44.9-48.9) | 85.8 (84.4-87.2) | 22.4 (20.7-24.1) | 83.1 (81.6-84.6) | 45.3 (43.3-47.3) | 98.8 (98.4-99.2) | 3.8 (3.0-4.6) | 96.0 (95.2-96.8) | 44.8 (42.8-46.8) | 99.9 (99.8-100) | 1.8 (1.3-2.3) | |||
| ≥8, 002 | 29.9 (28.1-31.7) | 77.9 (76.2-79.6) | 82.8 (81.3-84.3) | 23.9 (22.2-25.6) | 50.6 (48.6-52.6) | 77.3 (75.6-79.0) | 97.9 (97.3-98.5) | 6.8 (5.8-7.8) | 68.0 (66.1-69.9) | 76.9 (75.2-78.6) | 99.6 (99.3-99.9) | 3.0 (2.3-3.7) | |||
| Combination | 72.1 (70.3-73.9) | 43.3 (41.3-45.3) | 87.0 (85.7-88.3) | 22.8 (21.1-24.5) | 85.7 (84.3-87.1) | 41.3 (39.3-43.3) | 98.9 (98.5-99.3) | 4.6 (3.8-5.4) | 96.0 (95.2-96.8) | 40.8 (38.8-42.8) | 99.9 (99.8-100) | 1.7 (1.2-2.2) | |||