S1.

Genotype and allele frequencies of VEGI gene polymorphisms and LN metastasis status

SNP ID	Genotype	LN (+) No. (%)	LN (-) No. (%)	OR (95% CI)	P value
VEGI, vascular endothelial growth inhibitor; LN, lymph node.
rs6478106	CC	118 (46.46)	164 (42.60)	Reference
	CT	117 (46.06)	188 (48.83)	0.865 (0.622-1.204)	0.389
	TT	19 (7.48)	33 (8.57)	0.800 (0.434-1.476)	0.475
	Dominant			0.855 (0.622-1.176)	0.336
	Recessive			0.862 (0.479-1.553)	0.622
	Allelic			0.892 (0.701-1.135)	0.353
rs4263839	GG	59 (22.87)	116 (29.74)	Reference
	GA	149 (57.75)	209 (53.59)	1.402 (0.961-2.044)	0.079
	AA	50 (19.38)	65 (16.67)	1.512 (0.932-2.454)	0.093
	Dominant			1.428 (0.994-2.052)	0.054
	Recessive			1.202 (0.799-1.807)	0.376
	Allelic			1.213 (0.970-1.517)	0.090
rs4979462	CC	148 (58.73)	200 (51.55)	Reference
	CT	86 (34.13)	162 (41.75)	0.717 (0.512-1.005)	0.053
	TT	18 (7.14)	26 (6.70)	0.936 (0.495-1.770)	0.838
	Dominant			0.748 (0.543-1.030)	0.075
	Recessive			1.071 (0.574-1.997)	0.829
	Allelic			0.839 (0.648-1.085)	0.181
rs7848647	TT	67 (26.07)	86 (22.40)	Reference
	TC	142 (55.25)	209 (54.43)	0.872 (0.594-1.280)	0.485
	CC	48 (18.68)	89 (23.18)	0.692 (0.431-1.113)	0.128
	Dominant			0.818 (0.567-1.182)	0.285
	Recessive			0.761 (0.514-1.128)	0.173
	Allelic			0.849 (0.679-1.062)	0.151