S2.

Genotype and allele frequencies of VEGI gene polymorphisms and ER status

SNP ID	Genotype	ER (+) No. (%)	ER (-) No. (%)	OR (95% CI)	P value
VEGI, vascular endothelial growth inhibitor; ER, estrogen receptor.
rs6478106	CC	175 (45.45)	95 (43.18)	Reference
	CT	177 (45.97)	109 (49.55)	0.882 (0.624-1.245)	0.474
	TT	33 (8.57)	16 (7.27)	1.120 (0.586-2.139)	0.732
	Dominant			0.912 (0.653-1.273)	0.589
	Recessive			1.670 (0.894-3.119)	0.105
	Allelic			0.978 (0.760-1.257)	0.861
rs4263839	GG	113 (28.83)	57 (25.33)	Reference
	GA	203 (51.79)	134 (59.56)	0.764 (0.519-1.124)	0.172
	AA	76 (19.39)	34 (15.11)	1.128 (0.674-1.887)	0.648
	Dominant			0.841 (0.580-1.219)	0.360
	Recessive			1.351 (0.868-2.103)	0.182
	Allelic			1.016 (0.805-1.282)	0.894
rs4979462	CC	213 (54.48)	113 (52.31)	Reference
	CT	150 (38.36)	89 (41.20)	0.894 (0.632-1.266)	0.528
	TT	28 (7.16)	14 (6.48)	1.061 (0.537-2.096)	0.865
	Dominant			0.917 (0.657-1.279)	0.609
	Recessive			1.113 (0.573-2.162)	0.752
	Allelic			0.963 (0.739-1.255)	0.780
rs7848647	TT	95 (24.55)	50 (22.73)	Reference
	TC	210 (54.26)	122 (55.45)	0.906 (0.602-1.363)	0.636
	CC	82 (21.19)	48 (21.82)	0.899 (0.549-1.474)	0.673
	Dominant			0.904 (0.611-1.337)	0.613
	Recessive			0.980 (0.656-1.465)	0.922
	Allelic			0.952 (0.753-1.203)	0.681