Table 3.

Yields of crude extract (CE), total secondary metabolites (TSM), and individual secondary metabolites using the Box-Behnken experimental design for lab-scale SFE

Run	Design			CE (%)	HMDF (%)	HMF (%)	DMC (%)	BA (%)	UA (%)	TSM (%)
	X 1	X 2	X 3
1	−1	−1	0	0.5	2.08	0.53	10.2	11.49	2.33	26.65
2	1	−1	0	1.1	3.31	0.87	18.0	24.79	4.96	51.98
3	−1	1	0	0.1	0.73	0.19	4.6	0	0	5.55
4	1	1	0	1.3	2.26	0.58	12.8	21.31	9.25	46.25
5	−1	0	−1	0.2	0.88	0.32	5.9	13.83	2.25	23.19
6	1	0	−1	0.8	2.37	0.64	12.9	21.84	3.23	41.00
7	−1	0	1	0.2	0.98	0.30	8.0	11.13	1.35	21.77
8	1	0	1	0.8	3.00	0.80	17.2	20.79	2.96	44.80
9	0	−1	−1	0.8	2.02	0.55	11.7	21.04	3.23	38.56
10	0	1	−1	1.7	1.88	0.54	8.2	8.16	3.34	22.12
11	0	−1	1	0.8	2.37	0.62	12.2	9.46	3.04	27.77
12	0	1	1	1.6	2.09	0.50	11.1	6.98	2.07	22.82
13	0	0	0	1.8	2.19	0.60	12.2	9.98	4.04	29.09
14	0	0	0	1.8	2.04	0.58	13.0	9.89	4.26	29.79
15	0	0	0	1.8	2.11	0.63	12.0	9.93	3.98	28.68
16	0	0	0	1.7	2.34	0.65	11.8	9.90	4.00	28.88
17	0	0	0	1.7	2.29	0.59	12.0	9.85	3.76	29.56