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. 2016 Sep 7;4:e2347. doi: 10.7717/peerj.2347

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©2016 Samuel et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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PRC significantly increased the expression of Runx2 (A) , Col I (B), ALP (C), BMP2 (D) and osteopontin (E) compared to the osteogenic medium (OM) at various specific time points. No significant difference was observed in the expression of osteocalcin (F) by day 24. On the contrary, osteonectin (G) expression was significantly lower in the PRC group compared to the OM throughout the course of study. Results are expressed as fold change relative to the control (FBS medium). Data are expressed as the mean ± SD. * denotes statistical significance between the indicated pairs (p < 0.05).