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Chronic leucine supplementation improves lipid metabolism by decreased hepatic lipogenesis in mice fed with HFCD. Values are means for three rats with SD represented by vertical bars. *p<0.05 versus CD group, **p<0.01 versus CD group, ## p<0.01 versus HFCD group. CD, chow diet; HFCD, high-fat/cholesterol diet; Leu, leucine; FAS, fatty acid synthase; ACC, acetyl-coenzyme A carboxylase; SREBP-1, sterol regulatory element binding protein-1; LXRα, liver X receptor α.
