Table 4. Methodological Characteristics of Included Meta-analyses.

Authors	Primary study design	Level of evidence	Software	Sensitivity analysis	Subgroup analysis	GARDE evidence profiles
Lo et al.20	RCT	Level II	SAS	YES	-NO	NO
Wang et al.21	RCT	Level II	STATA	NO	YES	NO
Modawal et al.22	RCT	Level II	STATA	YES	NO	NO
Arrich et al.23	RCT	Level II	STATA	YES	NO	NO
Strand et al.24	RCT	Level II	SAS	NO	NO	NO
Bellamy et al.25	RCT	Level II	REVMAN	YES	NO	NO
Bannuru et al.9	RCT	Level II	R software	YES	YES	NO
Rutjes et al.10	RCT or quasi-RCT	Level II	STATA	YES	YES	NO
Colen et al.26	RCT	Level II	REVMAN	NO	NO	NO
Miller et al.11	RCT	Level II	Comprehensive Meta-analysis	YES	NO	NO
Richette et al.12	RCT	Level II	R software	NO	NO	NO
Strand et al.6	RCT	Level II	Comprehensive Meta-analysis	YES	YES	NO