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. 2016 Sep 12;6:32993. doi: 10.1038/srep32993

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The images (A) and migration rates of human fibroblasts following co-culture with 0, 25, 50, or 100 μg/mL ASCs-Exos for 12 h (B) or 24 h (C). Transwelltest of fibroblasts with stimulation of different concentrations of exsomes (D). Growth curves of fibroblasts co-cultured with 0, 25, 50, or 100 μg/mL ASC-Exos (F). The N-calcium (E) Cyclin-1 (G) and PCNA (H) mRNA expression of human fibroblasts. The Col I (I), III (J) and elastin (K) mRNA expression of human fibroblasts treated with ASCs-Exos.*P < 0.05, **P < 0.01, ***P < 0.001.