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The MrkHPilZ C-domain motif 2 and N-domain motif act as abutments for specifically binding a c-di-GMP intercalated dimer. Key glycines (blue) in each motif, G145 from motif 2 and G73 from the N-domain motif, allow tight packing of the outward-facing guanine bases of the intercalated c-di-GMP dimer. Motif 2 is colored pink and the N-domain motif is colored green.
