Table S5.

Clinical manifestations of patients with OTULIN mutations

Cell types	Patient 1		Patient 3		Normal range
CD3, no.	3,789	H	6,072	H	1,900–3,700
CD4/CD3, %	52.6		39.5		60–76%
CD4/CD3, no.	2,404	H	2,876	H	650–1,500/μL
CD8/CD3, %	22.3		31.7		11.2–34/8%
CD8/CD3, no.	1,019	H	2,308	H	370–1,100/μL
CD19, %	10	L	12.8	L	13–27%
CD19, no.	457		932	H	270–860/μL
NK cells, %	7		3.7	L	4–17%
NK cells, no.	320		269		100–480/μL

Lymphocyte phenotyping in patients 1 and 3. Patient 2 was not available for immunophenotyping. NK, natural killer.