Fig. 5.
Eliminating endogenous MIF accelerates disease onset and late disease progression and shortens the survival of SOD1G85R mice. (A–C) Mean age (± SD) of disease onset, defined as the time when mice reached peak body weight (P < 0.05) (A); early disease, defined as the time when mice lost 10% of their maximal weight (P < 0.05) (B); and disease end stage, defined as the time when the mouse could not right itself within 20 s when placed on its side (P < 0.01) (C) of SOD1G85R/MIF+/+ mice (red) and their SOD1G85R/MIF−/− littermates (blue). (D–F) Mean (± SD) age of disease onset (P < 0.05) (D), duration of early disease (from onset to 10% weight loss; P = 0.406) (E), and duration of late disease (from 10% weight loss to end stage; P < 0.01) (F). At each time point, the P value was determined by Student’s t test. Error bars denote SD.