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. 2016 Aug 15;113(36):10085–10090. doi: 10.1073/pnas.1601895113

Fig. 1.

Fig. 1.

Herpesvirus infection in mice is regulated by the circadian clock. (A) WT female mice were intranasally infected with M3:luciferase Murid Herpesvirus 4 (M3:luc MuHV-4) at Zeitgeber Time 0 (ZT0) (lights on; n = 6) or at ZT10 (n = 6). Schematic illustrates Bmal1 mRNA levels and active (genome-bound) BMAL1 protein over the day and night. Infection was monitored by bioluminescence imaging. Primary infection in the nose is higher in mice inoculated at the onset of the resting phase (ZT0) compared with infection before the active phase (ZT10) [mean ± SEM; two-way ANOVA (ZT of infection × time postinfection): ZT of infection effect, P = 0.0021; post hoc t tests, *P < 0.05]. See also Fig. S1A. (B) Female Bmal1−/− mice were infected with M3:luc MuHV-4 at either ZT0 (n = 5) or ZT10 (n = 6) and infection monitored as for A [mean ± SEM; two-way ANOVA (ZT of infection × time postinfection): ZT of infection effect, P > 0.05; NS = not significant). See also Fig. S1B.