Table S2.
Enrichment cluster scores and P values of DAVID enrichment analysis
| Gene ontology term | Gene IDs | Fold enrichment | P |
| Enrichment Score: 2.235 | |||
| Hydrogen ion transmembrane transporter activity | UQCRH, COX6B1, ATP6V1H, ATP5A1, COX5A | 22.51 | 6.10E-05 |
| Generation of precursor metabolites and energy | NDUFB11, IDH3G, UQCRH, ATP6V1H, ATP5A1 | 7.44 | 3.92E-03 |
| Mitochondrial inner membrane | NDUFB11, UQCRH, COX6B1, ATP5A1, COX5A | 6.81 | 5.19E-03 |
| Oxidative phosphorylation | UQCRH, ATP6V1H, ATP5A1 | 20.80 | 8.60E-03 |
| Mitochondrial membrane | NDUFB11, UQCRH, COX6B1, ATP5A1, COX5A | 5.48 | 1.10E-02 |
| Mitochondrial envelope | NDUFB11, UQCRH, COX6B1, ATP5A1, COX5A | 5.16 | 1.36E-02 |
| Organelle membrane | NDUFB11, UQCRH, COX6B1, ATP6V1H, ATP5A1, COX5A | 2.99 | 4.15E-02 |
| Enrichment Score: 2.219 | |||
| Nucleosome | HIST1H2AB, HIST1H2AA, HIST1H2AF, HIST1H2AD, HIST1H2AH, HIST3H2A | 26.02 | 4.28E-04 |
| Protein-DNA complex | HIST1H2AB, HIST1H2AA, HIST1H2AF, HIST1H2AD, HIST1H2AH, HIST3H2A | 21.51 | 7.49E-04 |
| Nucleosome assembly | HIST1H2AB, HIST1H2AA, HIST1H2AF, HIST1H2AD, HIST1H2AH, HIST3H2A | 21.27 | 7.90E-04 |
| Chromatin assembly | HIST1H2AB, HIST1H2AA, HIST1H2AF, HIST1H2AD, HIST1H2AH, HIST3H2A | 20.71 | 8.55E-04 |
| DNA packaging | HIST1H2AB, HIST1H2AA, HIST1H2AF, HIST1H2AD, HIST1H2AH, HIST3H2A | 15.38 | 2.02E-03 |
| Cellular macromolecular complex subunit organization | HIST1H2AB, HIST1H2AA, HIST1H2AF, HIST1H2AD, HIST1H2AH, HIST3H2A, STMN1 | 7.92 | 3.13E-03 |
| Chromosome | HIST1H2AB, HMGB2, HIST1H2AA, HIST1H2AF, HIST1H2AD, HIST1H2AH, HIST3H2A | 5.34 | 1.21E-02 |
| Enrichment Score: 2.012 | |||
| Lamellipodium | DBNL, WASF2, ABI2, ABI1 | 25.61 | 4.49E-04 |
| Cell leading edge | DBNL, WASF2, ABI2, ABI1 | 14.41 | 2.38E-03 |
| Cytoskeleton | DBNL, UTRN, WASF2, ABI2, ABI1, MARCKS, STMN1, TPM1 | 2.88 | 1.49E-02 |
| Cell projection | DBNL, UTRN, WASF2, ABI2, ABI1 | 3.51 | 4.70E-02 |
| Enrichment Score: 1.834 | |||
| Non–membrane-bounded organelle | HIST1H2AB, DBNL, HMGB2, HIST1H2AA, HIST1H2AF, HIST1H2AD, WASF2, UTRN, ABI2, GM5218, ABI1, TPM1, RPL29, HIST1H2AH, GM10709, MARCKS, HIST3H2A, STMN1 | 2.94 | 2.30E-04 |
| Cytoskeletal protein binding | DBNL, UTRN, WASF2, MARCKS, STMN1, TPM1 | 5.35 | 4.30E-03 |
| Actin binding | DBNL, UTRN, WASF2, MARCKS, TPM1 | 6.41 | 6.67E-03 |
| Cytoskeleton | DBNL, UTRN, WASF2, ABI2, ABI1, MARCKS, STMN1, TPM1 | 2.88 | 1.49E-02 |
| Cell cortex | DBNL, UTRN, MARCKS | 9.60 | 3.65E-02 |
| Enrichment Score: 1.494 | |||
| Oxidative phosphorylation | UQCRH, ATP6V1H, ATP5A1 | 20.80 | 8.60E-03 |
| Phosphorylation | GALK1, UQCRH, ABI2, ATP6V1H, ABI1, ATP5A1 | 3.24 | 3.17E-02 |
| Enrichment Score: 0.536 | |||
| Oxidation reduction | CYB5R1, NDUFB11, IDH3G, UQCRH, AOC2, AOC3 | 3.47 | 2.47E-02 |
DAVID functional annotation clustering analysis for proteins whose abundance significantly changes at CT18 vs. CT30 and is significantly decreased in Bmal1−/− cells compared with WT cells at both CT18 and CT30. Gene ontology terms with P < 0.05 shown. See Fig. 6D for diagrammatic presentation of results.