Table 2.
Tumors from individuals should be tested for MSI in the following situations
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Hereditary non-polyposis colorectal cancer (HNPCC)-related tumors include colorectal, endometrial, stomach, ovarian, pancreas, ureter and renal pelvis, biliary tract, and brain (usually glioblastoma as seen in Turcot syndrome) tumors, sebaceous gland adenomas and keratoacanthomas in Muir–Torre syndrome, and carcinoma of the small bowel.
MSI-H, microsatellite instability–high in tumors. (Refers to changes in two or more of the five National Cancer Institute-recommended panels of microsatellite markers.)
Presence of tumor-infiltrating lymphocytes, Crohn’s-like lymphocytic reaction, mucinous/signet-ring differentiation, or medullary growth pattern.
There was no consensus among the workshop participants on whether to include the age criteria in guideline three above; participants voted to keep less than 60 years of age in the guidelines.