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. 2016 Sep 12;6:33277. doi: 10.1038/srep33277

Figure 4. In vivo evaluation of FBR-associated cell-cell fusion on BMG nanorod arrays.

Figure 4

Flat BMGs and BMG-55s were implanted IP in WT mice for 7 days. Explanted BMGs were stained and analyzed as described. (a,b) Explanted BMGs stained for F-actin (phalloidin) and nuclei (DAPI). Scale bar = 7 μm. (c–g) Quantification of fusion parameters. Fusion index was defined as the ratio of number of fused nuclei to total nuclei. BMG-55s resulted in attenuation of cell-cell fusion in in vivo settings. Fusion index, number of FBGCs, nuclei per FBGC and average area of FBGCs were significantly reduced on BMG-55s. Total number of nuclei per field of view was found to be larger on BMG-55s. (n = 6). Error bars represent standard error mean (SEM). *p ≤ 0.05 for significance, t-test, compared to corresponding values in flat BMG controls.