Table 3. Distribution of allelic and genotypic frequencies of HTR3 SNPs and their associations with the risk of OCD.
| SNP | Alleles |
Genotypes |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| D/da | OCDb | Controlb | P valuec | OCDd | Controld | ORdom (95% CI); P value | ORrec (95% CI); P value | ORovd (95% CI); P value | ORadd (95% CI); P value | |
| rs1062613 | C/T | 0.112 | 0.112 | 0.9482 | 474/110/12 | 467/125/4 | 1.03 (0.76–1.39); 0.8509 | 3.51 (1.06–11.63); 0.0296e | 0.94 (0.69–1.27); 0.6757 | 1.11 (0.84–1.45); 0.4736 |
| rs1176713 | A/G | 0.255 | 0.247 | 0.6524 | 340/204/49 | 339/211/40 | 1.03 (0.80–1.32); 0.8087 | 1.11 (0.69–1.79); 0.6564e | 1.00 (0.77–1.30); 0.9931 | 1.04 (0.85–1.26); 0.7082 |
| rs3758987 | T/C | 0.233 | 0.268 | 0.0481 | 345/214/30 | 315/228/43 | 0.81 (0.63–1.04); 0.0958 | 0.57 (0.33–0.97); 0.0365 | 0.91 (0.71–1.18); 0.4950 | 0.80 (0.65–0.98); 0.0299e |
| rs1176744 | A/C | 0.206 | 0.250 | 0.0104 | 376/195/25 | 337/216/40 | 0.75 (0.58–0.97); 0.0253 | 0.46 (0.26–0.82); 0.0068 | 0.87 (0.67–1.13); 0.2998 | 0.74 (0.60–0.91); 0.0043e |
| rs3782025 | A/G | 0.344 | 0.308 | 0.0574 | 253/265/70 | 290/226/66 | 1.41 (1.09–1.81); 0.0078e | 1.21 (0.82–1.79); 0.3276 | 1.30 (1.01–1.68); 0.0403 | 1.25 (1.04–1.51); 0.0159 |
| rs6766410 | A/C | 0.403 | 0.404 | 0.9667 | 200/310/85 | 208/293/94 | 1.00 (0.77–1.29); 0.9729 | 0.80 (0.57–1.14); 0.2161e | 1.11 (0.87–1.42); 0.3970 | 0.94 (0.78–1.13); 0.5003 |
| rs6807362 | C/G | 0.265 | 0.266 | 0.9410 | 318/239/38 | 321/227/44 | 1.00 (0.78–1.28); 0.9853 | 0.79 (0.48–1.30); 0.3579e | 1.07 (0.83–1.37); 0.6247 | 0.96 (0.79–1.18); 0.7222 |
| rs6443930 | C/G | 0.438 | 0.451 | 0.5300 | 185/298/111 | 179/297/120 | 1.05 (0.80–1.38); 0.7164 | 0.93 (0.68–1.26); 0.6249 | 1.10 (0.86–1.40); 0.4688e | 1.00 (0.84–1.19); 0.9673 |
| rs1000952 | A/G | 0.078 | 0.087 | 0.4132 | 509/81/6 | 494/100/2 | 0.78 (0.56–1.10); 0.1559 | 3.19 (0.61–16.62); 0.1410 | 0.73 (0.51–1.03); 0.0731e | 0.85 (0.62–1.17); 0.3129 |
| rs7627615 | A/G | 0.215 | 0.220 | 0.7610 | 366/202/27 | 364/203/30 | 0.93 (0.72–1.20); 0.5736 | 0.83 (0.46–1.51); 0.5478 | 0.96 (0.74–1.25); 0.7536 | 0.93 (0.75–1.15); 0.4916e |
OCD, obsessive-compulsive disorder; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; dom, dominant; rec, recessive; ovd, overdominant; add, additive.
aLowercase d denotes the less frequent allele.
bMinor allele frequencies in individuals with OCD and controls.
cP values via Pearson’s χ2 test for allelic associations.
dNumber of genotypes in individuals with OCD and controls. Order of genotypes: DD/Dd/dd (d is the minor allele).
eGenetic inheritance model with the lowest Akaike information criteria.