Table 2. Rabbit Pharmacodynamic Profile for Compounds 6a and 13k (3 mg/kg Infusion over 30 min, Parameters at 20 min, n = 3 or n = 4).

	compound 6a	compound 13k
vehicle	DMF	DMF
% AERP increase	9 ± 2.4	21.4 ± 2.8
% change in BP (systolic, mean BP)	0.1 ± 5.4, –1.0 ± 4.9	–3.4 ± 3.1, –3.8 ± 4.0
% change in heart rate	–3.2 ± 4.1	–3.1 ± 2.0
plasma exposure (μM)	9.1 ± 1.1	2.7 ± 1.5