Figure 6. Phylogenetic analysis of 17 598 P450s belonging to 113 families from different biological kingdoms such as bacteria, fungi, animals and plants.

All 113 P450 families were grouped under 15 clans based on their phylogenetic relationships and following the methods described elsewhere⁸. Clans were presented in different colors and the host containing the respective P450 families that grouped under each clan is shown in schematic diagrams. Schematic diagrams are representative only and the P450 family is not necessarily confined to the depicted animals. Cartoon figures for plants, bacteria and fungi are shown as representative of their kingdoms. The tree was viewed by Hypertree in fisheye pattern. Detailed information on clan-level grouping of 113 P450 families is presented in Supplementary Table S10 and functional data on P450s at family level is presented in Supplementary Table S11.