FIG 1.

Overview of antibiofilm peptide activity based on the example of IDR-1018. The peptide structure was originally published by Wieczorek et al. (56), and the structural coordinate file was kindly provided by Suzana Straus. (Republished from reference 39.) (A) Antibiofilm peptides are able to inhibit developed biofilms and kill multiple species in biofilms, including the ESKAPE pathogens. (B) Antibiofilm peptides show strong synergy with several antibiotics, thereby completely eradicating preformed biofilms. (C) Antibiofilm peptides act by targeting a universal stress response in bacteria.