FIGURE 4.

Killing kinetics of synthetic peptides against B. pseudomallei. Bacterial suspensions were treated with (A) LL-37, (B) NLP-31 and (C) Y43C5A.3 at 0× MIC₉₀ (○), 1× MIC₉₀ (■), 2× MIC₉₀ (▴), 4× MIC₉₀ (×) and 8× MIC₉₀ (◆) and CFU/ml was enumerated at indicated time points. Untreated bacterial suspension was included as the control. A bactericidal effect was defined as a ≥3 log10 reduction in CFU/ml compared with the initial inoculum. Data are the mean ± SEM of two independent experiments performed in triplicate (n = 6).