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. 2016 Sep;6(3):261–273. doi: 10.1086/687293

Figure 1.

Figure 1

Pathways involved in linoleic and arachidonic acid metabolism. A, Linoleic acid is metabolized by 5- and 15-lipoxygenase (LOX) to form 9-hydroxyoctadecadienoic acid (9-HODE) and 13-HODE, respectively. Linoleic acid can also be metabolized to arachidonic acid. In turn, arachidonic acid is used to form prostaglandins (by cyclooxygenases) and epoxides (by the cytochrome p450 epoxygenase pathway). B, Arachidonic acid can also be metabolized to 5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE by LOXs and to leukotrienes (LTs) such as LTA4 (by LTA4-synthase), LTB4 (by LTA4-hydrolase), LTC4 (by LTC4-synthase), LTD4 (by γ-glutamyl-transferase), and LTE4 (by peptidase).