Figure 3.

The Wnt signaling pathways regulate gene expression and cell movements. The Wnt/βC pathway (A) controls gene expression through DVL-dependent activation and nuclear shuttling of βC, while Wnt/PCP (B) modulates motility, polarity, and tissue morphogenesis thru DVL activation of RhoA/Rac1/cdc42. Specific domains within Dvl are responsible for differentia activation of βC (DIX) or PCP (PDZ/DEP). βC: β-catenin; DVL: protein disheveled; FZD: frizzled family of receptors; GSK3: glycogen synthase kinase 3; LRP: low-density lipoprotein receptor–related protein; PCP: planar cell polarity; ROR2: receptor tyrosine kinase-like orphan receptor 2.