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Proposed role of Wnt signaling in pulmonary vascular homeostasis. A, Wnt/βC and Wnt/PCP coordinate endothelial growth and movement during vascular repair in response to injury. B, Loss of Wnt signaling results in impaired angiogenesis and is permissive to PASMC-driven obliterative vasculopathy. βC: β-catenin; PASMC: pulmonary artery smooth muscle cell; PCP: planar cell polarity.
