Transplantation-free survival. A, Stratified by the Nice CHD classification. Survival at 1, 3, and 5 years was 96%, 92% and 82% for children in group 1, 100%, 100%, and 100% for children in group 2, 94%, 89%, and 89% for children in group 3, and 97%, 94%, and 89% for children in group 4, respectively (P = 0.45). Also shown is survival for children with not-classifiable PAH-CHD, with 1-, 3-, and 5-year survival of 90%, 70%, and 70%, respectively. B, Stratified by the hemodynamic relevance of the shunt defect. Survival at 1, 3, and 5 years was 98%, 95%, and 89% for children with a hemodynamically relevant shunt defect (groups 1+2) and 95%, 89%, and 86% for children without a hemodynamically relevant shunt defect (groups 3+4 and not-classifiable PAH-CHD), respectively (P = 0.30). CHD: congenital heart disease; PAH: pulmonary arterial hypertension.