Table S2.
Clinical and hemodynamic characteristics of patients with no PH in cohorts A and B
| Cohort A | ||||
|---|---|---|---|---|
| Category | Total | Before fluid challenge | After fluid challenge | Cohort B |
| Clinical characteristics | ||||
| Patients, no. | 28 | 1,969 | ||
| Age, mean, years | 51 ± 15 | 60 ± 15 | ||
| Sex, % female | 89 | 47 | ||
| Hemodynamic characteristics | ||||
| Heart rate, beats/min | 77 ± 15 | 76 ± 14 | 73 ± 15 | |
| Mean arterial pressure, mmHg | 95 ± 11 | 96 ± 14 | 89 ± 22 | |
| Right atrial pressure, mmHg | 5 ± 4 | 7 ± 4 | 5 ± 4 | |
| Systolic PAP, mmHg | 29 ± 10 | 36 ± 9 | 28 ± 7 | |
| Diastolic PAP, mmHg | 12 ± 4 | 15 ± 6 | 10 ± 5 | |
| Pulmonary artery pulse pressure, mmHg | 17 ± 7 | 20 ± 6 | 18 ± 6 | |
| Mean PAP, mmHg | 17 ± 6 | 23 ± 6 | 18 ± 4 | |
| PWP, mmHg | 8 ± 3 | 12 ± 4 | 9 ± 4 | |
| TPG, mmHg | 9 ± 5 | 11 ± 6 | 8 ± 3 | |
| DPG, mmHg | 3 ± 4 | 4 ± 5 | 1 ± 4 | |
| SVR, Wood units | 14.1 ± 4.8 | 13.7 ± 4.4 | 16.6 ± 5.4 | |
| Pulmonary artery saturation, % | 75 ± 8 | 75 ± 9 | 72 ± 8 | |
| Stroke volume, mL | 93 ± 33 | 99 ± 40 | 86 ± 31 | |
| Cardiac output, L/min | 7.0 ± 1.9 | 7.1 ± 1.8 | 6.0 ± 1.9 | |
| Cardiac index, L/min/m2 | 3.6 ± 0.9 | 3.8 ± 1.0 | 3.2 ± 1.0 | |
| PVR, Wood units | 1.4 ± 1.8 | 1.6 ± 0.9 | 1.7 ± 0.9 | |
| RVSWI, g/m2/beat | 3.8 ± 1.7 | 4.5 ± 2.2 | 4.5 ± 2.3 | |
| PVC, mL/mmHg | 7.0 ± 6.2 | 5.2 ± 2.5 | 5.4 ± 2.9 | |
| RC time, seconds | 0.46 ± 0.34 | 0.44 ± 0.18 | 0.49 ± 0.29 | |
Note
DPG: diastolic pulmonary artery pressure–to–pulmonary wedge pressure gradient; PAP: pulmonary arterial pressure; PH: pulmonary hypertension; PVC: pulmonary vascular compliance; PVR: pulmonary vascular resistance; PWP: pulmonary wedge pressure; RC time: resistance-compliance time; RVSWI: right ventricular stroke work index; SVR: systemic vascular resistance; TPG: transpulmonary gradient.