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. 2016 Sep;6(3):360–368. doi: 10.1086/688060

Figure 1.

Figure 1

Effect of chronic hypoxia on lung and heart remodeling and pulmonary vascular resistance in wild-type (WT) and Cyp2c44 knockout (Cyp2c44−/−) female and male mice. A, Representative micrographs of lung sections from normoxic (Norx) and hypoxic (Hypx) WT and Cyp2c44−/− females and males stained with hematoxylin and eosin show medial thickening of arterial wall, perivascular cuffing, and blood cells/thrombus in pulmonary vessels of hypoxic knockout mice. B, Summary data of pulmonary artery acceleration time to ejection time ratio (PAAT/ET) ratio. C, Right ventricle (RV) hypertrophy determined by Fulton index in WT and Cyp2c44−/− group is demonstrated. N = 5 in each group. Asterisk indicates P < 0.05 versus normoxia (Nor) controls, and pound sign indicates P < 0.05 versus WT hypoxia. Magnification ×20. LV+S: left ventricle plus septum.