Table 2.
Wild type | Cyp2c44−/− | |||
---|---|---|---|---|
Control | Chronic hypoxic pulmonary hypertension | Control | Chronic hypoxic pulmonary hypertension | |
CI (mL/min/m2) | 1,302 ± 89.38 | 308.1 ± 19.03a | 1,344 ± 114.8 | 304.6 ± 36.01a |
SV (μL) | 29.83 ± 1.50 | 5.90 ± 0.91a | 28.50 ± 2.09 | 6.03 ± 0.50 |
EDV (μL) | 84.78 ± 2.28 | 26.31 ± 2.56a | 72.96 ± 3.59 | 29.00 ± 2.59a |
ESV (μL) | 60.20 ± 2.71 | 21.62 ± 1.87a | 48.64 ± 2.45 | 25.21 ± 2.39a |
LV stiffness (mmHg/μL) | 4.31 ± 0.17 | 21.89 ± 4.91a | 4.43 ± 0.15 | 18.26 ± 3.85a |
Ea (mmHg/μL) | 3.57 ± 0.13 | 14.63 ± 2.22a | 3.10 ± 0.22 | 14.49 ± 1.82a |
TPR (mmHg × min/mL) | 7.58 ± 0.38 | 34.51 ± 4.38a | 6.92 ± 0.55 | 34.20 ± 2.90a |
Data are mean ± standard deviation. CI: cardiac index; Ea: arterial elastance; EDV: end-diastolic volume; ESV: end-systolic volume; LV: left ventricle; SV: stroke volume; TPR: total peripheral resistance.
P < 0.05 versus control; N = 5.