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. 2016 Jan 10;35(13):2195–2205. doi: 10.1002/sim.6853

Table 1.

Summary of key outcomes for CHARM‐Added and CHARM‐Alternative.Composite of first investigator reported HF hospitalisation or CV death.

CHARM‐Added CHARM‐Alternative
Placebo Candesartan Placebo Candesartan
Randomised 1272 1276 1015 1013
Total follow‐up (years) 3713 3848 2584 2660
All cause deaths 412 377 296 265
CV deaths 347 302 252 219
Unadjudicated composite 561 497 412 340
1 HFH 380 323 289 211
2 HFH 187 131 126 94
Number of HFHs:
1 193 192 163 117
2 91 74 58 45
3 37 24 29 21
4 21 14 16 9
5 19 8 8 10
6 6 4 7 3
7 5 3 2 2
8 3 2 3 3
9 1 0 1 0
10 1 2 2 1
11 2 0 0 0
12 1 0 0 0
Total HFH 813 589 579 422

CHARM: Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity.