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. 2016 Sep 6;11:4465–4477. doi: 10.2147/IJN.S113723

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© 2016 Hong et al. This work is published and licensed by Dove Medical Press Limited

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Effect of C300 incorporation on the appearance and stability of PTX-loaded liposoems.

Notes: Effect of C300 incorporation on (A) the extent of foaming during liposomal preparation process and (B–D) time-dependent changes of (B) mean particle size, (C) PI, and (D) the loaded PTX concentration of PEGylated/saturated PC-based liposomes. Liposomes were prepared with 35:5:2 mixture of DMPC:CHOL:PE-PEG with or without incorporation of 2 mg of C300. Data are expressed as mean ± SD (n=3). Significant differences are indicated by *P<0.05; **P<0.005 compared to initial condition.

Abbreviations: C300, Captex 300; CHOL, cholesterol; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; PE-PEG, N-(Carbonyl-methoxypolyethyleneglycol 2000)-1, 2-distearoyl-sn-glycero-3-phosphoethanolamine; PI, polydispersity index; PTX, paclitaxel; SD, standard deviation.