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. 2016 Sep 6;11:4465–4477. doi: 10.2147/IJN.S113723

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© 2016 Hong et al. This work is published and licensed by Dove Medical Press Limited

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Long-term stability of triglyceride-incorporated/saturated PC-based liposomes.

Notes: Long-term stability of triglyceride-incorporated/saturated PC-based liposomes assessed as changes in mean droplet size (A), PI (B), and remained PTX concentration (C) of liposomes. *P<0.05; **P<0.005 compared to initial condition. (D) Effects of triglyceride incorporation on the remained PTX in freeze-dried liposomes. PTX-loaded liposomes were prepared with a 7:1:0.4 of DMPC:CHOL:PE-PEG mixture with or without C300 (2 mg per 42 μmole lipid). Each point represents the mean ± SD (n=3).

Abbreviations: C300(−), Captex 300-free liposomes; C300(+), Captex 300-incorporated liposomes; CHOL, cholesterol; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; PE-PEG, N-(Carbonyl-methoxypolyethyleneglycol 2000)-1, 2-distearoyl-sn-glycero-3-phosphoethanolamine; PTX, paclitaxel; SD, standard deviation; PI, polydispersity index.