Table 4.
Multivariable‐adjusted hazard ratios per genotype in previous smokers
| Genotype | CC | CT | TT | Ptrenda | Ptrendb | ||
|---|---|---|---|---|---|---|---|
| End‐point | Events (total casesa , b) | Event/1000 py‐s | HR 95% CIa | ||||
| Incident COPD | 211 (8394) | 1.73 | 1.0 (ref) |
1.086 0.814–1.449 |
1.265 0.819–1.955 |
0.293 | 0.292 |
| Incident tobacco‐related cancer | 693 (7919) | 5.80 | 1.0 (ref) |
1.101 0.939–1.290 |
1.241 0.975–1.581 |
0.063 | 0.062 |
| Incident other cancer | 1218 (8071) | 10.36 | 1.0 (ref) |
0.917 0.814–1.033 |
0.934 0.766–1.140 |
0.206 | 0.212 |
| Incident CVD | 1047 (8025) | 9.33 | 1.0 (ref) |
1.007 0.885–1.144 |
0.991 0.805–1.219 |
0.987 | 0.865 |
| Total mortality | 1425 (8426) | 11.90 | 1.0 (ref) |
1.165 1.044–1.301* |
1.214 1.020–1.444* |
0.004* | 0.004* |
| CVD mortality | 488 (8425) | 4.18 | 1.0 (ref) |
1.373 1.137–1.659* |
1.281 0.945–1.736 |
0.006* | 0.005* |
| Respiratory disease mortality | 70 (8390) | 0.59 | 1.0 (ref) |
1.379 0.832–2.285 |
1.543 0.725–3.283 |
0.160 | 0.166 |
| Cancer mortality | 614 (8426) | 5.13 | 1.0 (ref) |
1.044 0.882–1.236 |
1.195 0.923–1.547 |
0.216 | 0.218 |
COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; p‐ys, patient‐years; HR, hazard ratio; CI, confidence interval.
aAdjusted for age and sex. bAdjusted for age, sex, body mass index (BMI), hypertension, previous diabetes and lipid‐lowering treatment.
*P < 0.05.