Table 5.
Multivariable‐adjusted hazard ratios per genotype in never smokers
| Genotype | CC | CT | TT | Ptrenda | Ptrendb | ||
|---|---|---|---|---|---|---|---|
| End‐point | Events (total casesa , b) | Events/1000 p‐ys | HR 95% CIa | ||||
| Incident COPD | 79 (9314) | 0.56 | 1.0 (ref) |
1.269 0.801–2.013 |
0.731 0.306–1.744 |
0.990 | 0.987 |
| Incident tobacco‐related cancer | 559 (8975) | 4.27 | 1.0 (ref) |
1.079 0.906–1.286 |
0.974 0.733–1.293 |
0.789 | 0.790 |
| Incident other cancer | 1233 (8906) | 9.20 | 1.0 (ref) |
0.983 0.874–1.106 |
0.860 0.708–1.044 |
0.200 | 0.213 |
| Incident CVD | 955 (9268) | 7.18 | 1.0 (ref) |
0.935 0.818–1.070 |
0.878 0.708–1.089 |
0.176 | 0.180 |
| Total mortality | 1143 (9416) | 8.34 | 1.0 (ref) |
0.965 0.854–1.091 |
0.909 0.746–1.107 |
0.327 | 0.309 |
| CVD mortality | 350 (9415) | 2.60 | 1.0 (ref) |
0.814 0.650–1.018 |
0.894 0.634–1.261 |
0.184 | 0.152 |
| Respiratory disease mortality | 33 (9310) | 0.24 | 1.0 (ref) |
0.792 0.385–1.632 |
0.572 0.206–2.390 |
0.460 | 0.452 |
| Cancer mortality | 520 (9406) | 3.80 | 1.0 (ref) |
1.033 0.863–1.237 |
0.811 0.595–1.106 |
0.416 | 0.414 |
COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; p‐ys, patient‐years; HR, hazard ratio; CI, confidence interval.
aAdjusted for age and sex. bAdjusted for age, sex, body mass index (BMI), hypertension, previous diabetes and lipid‐lowering treatment.