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. 2015 Dec 22;279(4):388–398. doi: 10.1111/joim.12454

Table 5.

Multivariable‐adjusted hazard ratios per genotype in never smokers

Genotype CC CT TT Ptrenda Ptrendb
End‐point Events (total casesa , b) Events/1000 p‐ys HR 95% CIa
Incident COPD 79 (9314) 0.56 1.0 (ref) 1.269
0.801–2.013
0.731
0.306–1.744
0.990 0.987
Incident tobacco‐related cancer 559 (8975) 4.27 1.0 (ref) 1.079
0.906–1.286
0.974
0.733–1.293
0.789 0.790
Incident other cancer 1233 (8906) 9.20 1.0 (ref) 0.983
0.874–1.106
0.860
0.708–1.044
0.200 0.213
Incident CVD 955 (9268) 7.18 1.0 (ref) 0.935
0.818–1.070
0.878
0.708–1.089
0.176 0.180
Total mortality 1143 (9416) 8.34 1.0 (ref) 0.965
0.854–1.091
0.909
0.746–1.107
0.327 0.309
CVD mortality 350 (9415) 2.60 1.0 (ref) 0.814
0.650–1.018
0.894
0.634–1.261
0.184 0.152
Respiratory disease mortality 33 (9310) 0.24 1.0 (ref) 0.792
0.385–1.632
0.572
0.206–2.390
0.460 0.452
Cancer mortality 520 (9406) 3.80 1.0 (ref) 1.033
0.863–1.237
0.811
0.595–1.106
0.416 0.414

COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; p‐ys, patient‐years; HR, hazard ratio; CI, confidence interval.

aAdjusted for age and sex. bAdjusted for age, sex, body mass index (BMI), hypertension, previous diabetes and lipid‐lowering treatment.