. Author manuscript; available in PMC: 2016 Sep 12.

Published in final edited form as: Curr Opin Chem Biol. 2016 Jun 29;33:160–168. doi: 10.1016/j.cbpa.2016.06.019

Table 1. HDAC 1-3 in (NF-κB-mediated) inflammation.

HDAC	Activity/Level	Observed Effects	Refs
HDAC 1	↑ RA synovial fluid	↑ TNFα levels	[21]
	↓ Degradation	↑ TNFα and IL-1β levels	[22]
	↓ T cell-specific loss	↑ inflammatory response in vivo allergic airway inflammation model	[23]
HDAC 2	↓ Reduced levels	Observed in COPD patients	[24]
HDAC 2	↓ Reduced levels	Observed in smoking asthmatics compared to non-smoking asthmatics	[25]
HDAC 3	↓	↓ expression 50% of studied inflammatory genes in macrophages	[38]
	↓ siRNA knockdown	↓ vascular cell adhesion molecule-1; suppresses monocyte adhesion	[26]
	↓ siRNA knockdown	↓ disease progression in allergic skin inflammation mouse model	[27]
	↓ Activity after smoke	↑ inflammatory responses in alveolar macrophages	[28]
	↓ siRNA knockdown	↑ IL-8 and IL-1β production after LPS stimulation	[28]
	↓	Macrophages hyperresponsive to IL-4 stimulation	[29]