Table 1.
Patient and Tumor Characteristics
| Characteristic | Value (N = 410)a |
|---|---|
| Age, mean (SD), y | 59.6 (10.8) |
|
| |
| Sex | |
|
| |
| Male | 338 (82.4) |
|
| |
| Female | 72 (17.6) |
|
| |
| Smoking history | |
|
| |
| Yes | 224 (54.6) |
|
| |
| No | 114 (27.8) |
|
| |
| Unknown | 72 (17.6) |
|
| |
| Alcohol use history | |
|
| |
| Yes | 166 (40.5) |
|
| |
| No | 86 (21.0) |
|
| |
| Quit | 50 (12.2) |
|
| |
| Unknown | 108 (26.3) |
|
| |
| Subsite | |
|
| |
| Oropharynx | 364 (88.8) |
|
| |
| Supraglottic larynx | 24 (5.9) |
|
| |
| Hypopharynx | 9 (2.2) |
|
| |
| Posterolateral oral cavity | 9 (2.2) |
|
| |
| Other | 4 (1.0) |
|
| |
| Pathologic tumor stage | |
|
| |
| Tx | 18 (4.4) |
|
| |
| T0 | 12 (2.9) |
|
| |
| T1 | 170 (41.5) |
|
| |
| T2 | 172 (42.0) |
|
| |
| T3 | 28 (6.8) |
|
| |
| T4 | 10 (2.4) |
|
| |
| Pathologic nodal stage | |
|
| |
| N0 | 120 (29.2) |
|
| |
| N1 | 57 (13.9) |
|
| |
| N2a | 64 (15.6) |
|
| |
| N2b | 110 (26.8) |
|
| |
| N2c | 16 (3.9) |
|
| |
| N3 | 7 (1.7) |
|
| |
| Nx | 36 (8.8) |
|
| |
| Positive margins | |
|
| |
| Yes | 39 (9.9) |
|
| |
| No | 354 (86.3) |
|
| |
| Unknown | 17 (4.1) |
|
| |
| Close margins (1-5 mm) | |
|
| |
| Yes | 86 (21.0) |
|
| |
| No | 170 (41.5) |
|
| |
| Not specified | 154 (37.6) |
|
| |
| Perineural invasion | |
|
| |
| Yes | 67 (16.3) |
|
| |
| No | 234 (57.0) |
|
| |
| Not specified | 109 (26.6) |
|
| |
| Lymphovascular invasion | |
|
| |
| Yes | 78 (19.0) |
|
| |
| No | 217 (52.9) |
|
| |
| Not specified | 115 (28.0) |
|
| |
| Multiple nodal positivity | |
|
| |
| Yes | 110 (26.8) |
|
| |
| No | 241 (58.8) |
|
| |
| Unknown | 59 (14.4) |
|
| |
| Extracapsular spread | |
|
| |
| Yes | 58 (14.2) |
|
| |
| No | 100 (24.4) |
|
| |
| Unknown | 252 (61.5) |
|
| |
| HPV status (229 patients tested) | |
|
| |
| Negative | 70 (17.1) |
|
| |
| Positive | 159 (38.8) |
|
| |
| Unknown | 181 (44.1) |
|
| |
| p16 positivity (219 patients tested) | |
|
| |
| Negative | 61 (14.9) |
|
| |
| Positive | 158 (38.5) |
|
| |
| Unknown | 191 (46.6) |
|
| |
| Neck dissection | |
|
| |
| Yes | 323 (78.8) |
|
| |
| No | 77 (18.8) |
|
| |
| Unknown | 10 (2.4) |
|
| |
| Adjuvant treatment (338 patients) | |
|
| |
| Radiotherapy | 106 (25.9) |
|
| |
| Chemoradiotherapy | 72 (17.6) |
|
| |
| No adjuvant treatment received | 160 (39.0) |
|
| |
| Unknown | 72 (17.6) |
Abbreviation: HPV, human papillomavirus.
a
Data are presented as number (percentage) of patients unless otherwise indicated.