Table2.

Factors Associated With Locoregional Control and Overall Survival (N=410)

Factor	2-Year Locoregional Control, %	P Value for Log-Rank Testa	2-Year Overall Survival, %	P Value for Log-Rank Testa
Age, y
<60	94.6		87.6
		.01		.01
≥60	88.7		93.9
Sex
Male	91.8		89.1
		.94		.03
Female	91.9		98.6
Smoking history
Yes	88.8		86.0
		.01		.001
No	96.9		97.2
HPV
Positive	95.0		96.7
		.52		.23
Negative	92.0		93.7
p16
Positive	96.9		100
		.08		.13
Negative	87.6		94.9
Subsite
Tonsil vs all other	97.1	.01	95.4	.01
BOT vs all other	90.7	.99	92.1	.83
Oropharyngeal wall and faucial  arch vs all others	74.1	.001	81.8	.04
Soft palate vs all other sites	77.9	.19	100	.26
Positive margins
Yes	78.6		93.9
		.001		.36
No	92.9		90.9
Perineural invasion
Yes	94.4		86.3
		.82		.55
No	91.0		90.7
Lymphovascular invasion
Yes	100		88.6
		.01		.94
No	89.2		90.0
Tumor stage
T1-T2	91.7		90.1
		.50		.86
T3-T4	96.1		92.6
Nodal stage
N0	90.7	.16	91.0	.53
N1	93.6	.47	84.9	.12
N2a	94.7	.40	92.4	.72
N2b	100	.01	90.6	.88
N2c	100	.27	90.9	.68
N3	100	.47	100	.41
Nx	42.6	<.001	100	.52
Adjuvant treatment
None	86.6	.12	93.5	.58
Radiotherapy	98.9	.40	95.1	.14
Chemoradiotherapy	96.5	.16	81.0	.03

Abbreviations: BOT, base of tongue; HPV, human papillomavirus.

^aLog-rank test.